New Chemistry on Conventional Materials

主讲教师:程建军 人气:1606 更新时间: 2017年06月30日
Abstract: I will present two projects. First, I will present our work around helical polypeptides. I will report our design of helical, charged polypeptides, which has shown excellent cell membrane activity. These polypeptides have been broadly used in drug and gene delivery, cell membrane penetration and design of antimicrobial agents. I will then present our recent finding of helicity regulation via side chain hydrogen bonding. By controlling the hydrogen bonding donor and acceptor properties, we can precisely tune the helicity of polypeptides. I will report the integration of ring-opening metathesis polymerization and ring-opening polymerization of the amino acid N-carboxyanhydride to allow facile synthesis of brush-like polymers containing polypeptide brush. Cooperative polymerization of amino acid N-carboxyanhydride was found and the polymerization of controlled by the brush polypeptide helices. In the second portion of my talk, I will present sugar molecule mediated in vivo cancer targeting. We successfully developed azido-sugar derivatives that can label triple negative breast cancer and enable successful in vivo targeting. 程建军教授,1993年获天津南开大学化学学士学位,1996年获美国南伊利诺伊大学化学硕士学位,2001年获加州大学圣巴巴拉分校(University of California, Santa Barbara)材料科学博士学位。毕业后作为资深科学家在Insert Therapeutics工作三年至2004年,后又在麻省理工学院从事博士后研究至2005年,同年就职伊利诺伊大学厄巴纳 - 香槟分校(University of Illinois at Urbana-Champaign)材料科学与工程系任助理教授,2011年晋升为终身副教授,2015年晋升为该系终身正教授并获得伊利诺伊大学杰出晋升教授奖,2016年晋升为Hans Thurnauer 讲席教授。程建军教授课题组共发表过文章160余篇, 拥有/已申请37项美国或国际专利。获得的荣誉包括美国国家自然科学基金会青年学者奖和美国国立卫生研究院院长创新奖,以及五次伊利诺伊大学优秀教学奖。他是美国医学与生物工程学院会士(American Institute for Medical and Biological Engineering Fellow (AIMBE Fellow)),美国化学会高分子化学会士(ACS-POLY Fellow),美国科学促进会会士 (American Association for the Advancement of Science Fellow), 以及英国皇家化学会Biomaterials Science会刊的创刊副主编。研究领域包括高分子化学,多肽,纳米材料和纳米药物、药物输送、癌症靶向技术。


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